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Year : 1982  |  Volume : 14  |  Issue : 4  |  Page : 325--332

Effect of baclofen pretreatment on the antinociceptive and cataleptic effect of morphine in mice

JJ Balsara1, MP Muley2, AS Vadya3, AG Chandorkar4 
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Correspondence Address:
J J Balsara


Baclofen, the p-chlorophenyl analog of GABA, was found to exert antinociceptive activity and to induce catalepsy in mice. -Further pretreatment with sub-analgesic and sub cataleptic doses of baclofen was found to potentiate morphine-induced analgesia and catalepsy respectively. The possible mechanism involved in the induction of analgesia and catalepsy and in the potentiation of morphine-induced analgesia and catalepsy by baclofen is discussed on the basis of the inhibitory action of baclofen on the firing of the nigro-neostriatal dopaminergic neurons, which have been implicated in the control of nociceptive reflex activity and in the action of analgesic agents and whose hypofunctioning results in catalepsy.


How to cite this article:
Balsara J J, Muley M P, Vadya A S, Chandorkar A G. Effect of baclofen pretreatment on the antinociceptive and cataleptic effect of morphine in mice.Indian J Pharmacol 1982;14:325-332


How to cite this URL:
Balsara J J, Muley M P, Vadya A S, Chandorkar A G. Effect of baclofen pretreatment on the antinociceptive and cataleptic effect of morphine in mice. Indian J Pharmacol [serial online] 1982 [cited 2020 Sep 21 ];14:325-332
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1982;volume=14;issue=4;spage=325;epage=332;aulast=Balsara;type=0