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Year : 1982  |  Volume : 14  |  Issue : 2  |  Page : 163--168

Kinetics of lithium in normal volunteers

CB Khare1, A Sankaranarayanan2, SK Khandelwal3, KS Raghvan4, R Srinivasamurthy5 
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C B Khare


Six normal volunteers completed the study following oral administration of conventional and later slow release preparation of lithium carbonate. Mean serum levels over 24 h were calculated. The average time required to reach maximum concentration in serum was 5 h in conventional form and 6 h in case of slow release form. The maximum concentration did not differ significantly. The bio-availability of the conventional form was 79.9% of the slow release form. The volume of distribution and metabolic clearance rates for both the forms were similar. Implications of these findings are discussed.


How to cite this article:
Khare C B, Sankaranarayanan A, Khandelwal S K, Raghvan K S, Srinivasamurthy R. Kinetics of lithium in normal volunteers.Indian J Pharmacol 1982;14:163-168


How to cite this URL:
Khare C B, Sankaranarayanan A, Khandelwal S K, Raghvan K S, Srinivasamurthy R. Kinetics of lithium in normal volunteers. Indian J Pharmacol [serial online] 1982 [cited 2019 Dec 6 ];14:163-168
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1982;volume=14;issue=2;spage=163;epage=168;aulast=Khare;type=0