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Year : 1981  |  Volume : 13  |  Issue : 4  |  Page : 317--324

Central - adrenergic mechanism of catecholamine induced hypothermia in guinea pigs

RA Khan1, KP Gupta2 
1 
2 

Correspondence Address:
R A Khan


Intracerebroventricular administration of adrenaline, nor-adrenaline and phenylephrine through a chronically implanted cannula produced a fall followed by an after-rise in body temperature in guinea-pigs. Pretreatment with a-receptor antagonist tolazoline or phenoxybenzamine significantly reduced the hypothermia. Isoprenaline neither produced a significant fall in body temperature nor its slight hypothermic effect was blocked by propranolol. An involvement of central a-adrenoceptors in the production of catecholamine hypothermia in guinea-pig is suggested. The after-rise in temperature appears to be an unspecific fever.


How to cite this article:
Khan R A, Gupta K P. Central - adrenergic mechanism of catecholamine induced hypothermia in guinea pigs.Indian J Pharmacol 1981;13:317-324


How to cite this URL:
Khan R A, Gupta K P. Central - adrenergic mechanism of catecholamine induced hypothermia in guinea pigs. Indian J Pharmacol [serial online] 1981 [cited 2020 Aug 14 ];13:317-324
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1981;volume=13;issue=4;spage=317;epage=324;aulast=Khan;type=0