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Year : 1981  |  Volume : 13  |  Issue : 3  |  Page : 261--270

Studies on the effects of adrenaline, noradrenaline and phenylephrine on the estrogen primed rat myometrium

RK Goyal1, SC Verma2 
1 
2 

Correspondence Address:
R K Goyal


Adrenaline, noradrenaline and phenylephrine produed dose dependent relaxation of estrogen primed rat uterus. The responses to all three agonists were blocked competitively by propranolol (1.0x 10-6M to 1.0 x l0-7M), a specific ( receptor antagonist. Phentolamine (1.0x l0-6 M), a specific a receptor antagonist failed to inhibit these responses. The response to phenylephrine and noradrenaline were potentiated by caffeine perfusion (5.1 x l0-5M), a phosphodiesterase inhibitor, whereas imidazole perfusion (1.4x 10-4 M) inhibited the responses to phenylephrine and noradrenaline. Our data suggest specific ( receptor action of phenylephrine and noradrenaline in estrogen primed rat uterus. It is also suggestive that ( receptor action may be associated with adenylate cyclase cyclic 3«SQ»-5«SQ» adenosine monophosphate, (CAMP) system in this tissue.


How to cite this article:
Goyal R K, Verma S C. Studies on the effects of adrenaline, noradrenaline and phenylephrine on the estrogen primed rat myometrium.Indian J Pharmacol 1981;13:261-270


How to cite this URL:
Goyal R K, Verma S C. Studies on the effects of adrenaline, noradrenaline and phenylephrine on the estrogen primed rat myometrium. Indian J Pharmacol [serial online] 1981 [cited 2020 Feb 26 ];13:261-270
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1981;volume=13;issue=3;spage=261;epage=270;aulast=Goyal;type=0