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Year : 1981  |  Volume : 13  |  Issue : 3  |  Page : 245--251

Pharmacological investigation into the positive inotropic, chronotropic and hemodynamic effects of BDPU, [1-Butyl-3 (1-(6,7 dimethoxyquinzanoline 4-yl) piperidine –1-yl urea

SC Verma1, LN Iyengar2 
1 
2 

Correspondence Address:
S C Verma


BDPU [ (1-butyl-3(1,(6-7-dimethoxyquinoline-4-yl) piperidine 4-yl urea)] produced dose dependent (20 æg to 160 æg) positive inotropic effect on the isolated heart of guinea-pig. Reserpine pre-treatment (5 mg/kg., ip, 24 h) shifted the BDPU dose response curve to the 1eft. This may, be a supersensitive phenomena. In the anesthetized dog BDPU did not produce significant changes in blood pressure at doses 50, 100 and 200 æg/kg. At higher dose 400 æg/kg a fall in the mean arterial pressure was observed.Neither propranolol (l0-7M) nor phentolamine(10-7 M) produced any shift of the dose response curve of BDPU. Theophylline (l0-3M) and imidazole (20mM) perfusion did not alter BDPU responses. The positive inotropic responses of BDPU seem to be due to direct changes in calcium availability in the myocardium.


How to cite this article:
Verma S C, Iyengar L N. Pharmacological investigation into the positive inotropic, chronotropic and hemodynamic effects of BDPU, [1-Butyl-3 (1-(6,7 dimethoxyquinzanoline 4-yl) piperidine –1-yl urea.Indian J Pharmacol 1981;13:245-251


How to cite this URL:
Verma S C, Iyengar L N. Pharmacological investigation into the positive inotropic, chronotropic and hemodynamic effects of BDPU, [1-Butyl-3 (1-(6,7 dimethoxyquinzanoline 4-yl) piperidine –1-yl urea. Indian J Pharmacol [serial online] 1981 [cited 2020 Sep 21 ];13:245-251
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1981;volume=13;issue=3;spage=245;epage=251;aulast=Verma;type=0