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Year : 1977  |  Volume : 9  |  Issue : 3  |  Page : 221--224

Antiinflammatory, immunosuppressive and some related pharmacological actions of the water extract of Neem Giloe (Tinospora cordifolia): A preliminary report

VK Pendse1, AP Dadhich2, PN Mathur3, MS Bal4, BR Madan5 
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Correspondence Address:
V K Pendse


The water extract of the stem of Neem Giloe (Tinospora cordifolia), an Indian Indigenous plant, was screened for anti-inflammatory, analgesic and antipyretic actions in albino rats and immunosuppressive effect in albino rabbits. lt significantly inhibited acute inflammatory response evoked by carrageenin in a doss of 50 mg/100 g given orally and intraperitoneally. In chronic inflammation produced by croton-oil in granuloma pouch technique, 20 mg/100 g of the water extract significantly inhibited granulation tissue response; the reduction in exudative response and increase in t he weight of adrenal glands were not significant. A significant inhibition of primary and secondary phases was observed In adjuvant-induced arthritis. It significantly inhibited antibody formation by typhold DQHDQ antigen. A mild analgesic effect of its own as well as potentiation of morphine analgesia were possessed by the extract but it was devoid of antipyretic effect.


How to cite this article:
Pendse V K, Dadhich A P, Mathur P N, Bal M S, Madan B R. Antiinflammatory, immunosuppressive and some related pharmacological actions of the water extract of Neem Giloe (Tinospora cordifolia): A preliminary report.Indian J Pharmacol 1977;9:221-224


How to cite this URL:
Pendse V K, Dadhich A P, Mathur P N, Bal M S, Madan B R. Antiinflammatory, immunosuppressive and some related pharmacological actions of the water extract of Neem Giloe (Tinospora cordifolia): A preliminary report. Indian J Pharmacol [serial online] 1977 [cited 2019 Oct 20 ];9:221-224
Available from: http://www.ijp-online.com/article.asp?issn=0253-7613;year=1977;volume=9;issue=3;spage=221;epage=224;aulast=Pendse;type=0