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 RESEARCH ARTICLE
Year : 2020  |  Volume : 52  |  Issue : 3  |  Page : 172-178

Effectiveness of Deferasirox in Pediatric Thalassemia Patients: Experience from a Tertiary Care Hospital of Odisha


1 Department of Pharmacology, AIIMS, Bhubaneswar, Odisha, India
2 Department of Pharmacology, SLN Medical College, Koraput, Odisha, India
3 Clinical Haematology, SCB Medical College, Cuttack, Odisha, India
4 Department of Haemato-Oncology, AIIMS, Bhubaneswarar, Odisha, India
5 General Medicine, Vikash Multispeciality Hospital, Bargarh, Odisha, India

Correspondence Address:
Dr. Mousumee Panigrahi
KN-L-5/6, Kalyan Nagar, Budharaja, Sambalpur- 768 004, Odisha
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijp.IJP_68_18

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BACKGROUND AND OBJECTIVES: Patients with beta-thalassemia require lifelong blood transfusions, leading to chronic iron overload, which can lead to growth retardation, as well as hinder sexual development during the adolescent period and dysfunction of organs such as heart, pancreas, and endocrine glands. These patients are in need of lifelong transfusion therapy and hence lifelong iron chelation therapy as well. Hence, this study was aimed to assess the effectiveness of deferasirox for iron chelation in pediatric thalassemia cases in a tertiary care hospital of Eastern India. SUBJECTS AND METHODS: This prospective, observational, hospital-based study was conducted from June 2015 to December 2016. Two hundred and fifty patients were assessed for eligibility, of which 174 were included. Effectiveness of deferasirox was observed by measuring serum ferritin levels which were monitored at the end of every 3 months till 1 year. We also evaluated the compliance with deferasirox therapy in the same study cohort. RESULTS: The serum ferritin level reduced significantly at the end of 12 months in comparison to baseline (P = 0.04). There was a mean absolute decrease in serum ferritin only in the dose range of 21–30 mg/kg/day. Approximately 90% of the patients had 100% compliance with deferasirox therapy. CONCLUSIONS: Deferasirox is an effective iron chelator when started at an optimum time and with optimum dose. At least 1 year of deferasirox therapy is needed for a significant lowering of serum ferritin levels of pediatric thalassemia patients on multiple blood transfusions.






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