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Year : 2020  |  Volume : 52  |  Issue : 2  |  Page : 134-137

The effect of long-term valproic acid treatment in the level of total cholesterol among adult


1 Department of Neurology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia
2 Department of Medical Biology and Biochemistry, Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Correspondence Address:
Santoso Jaeri
Department of Medical Biology and Biochemistry, Faculty of Medicine, Diponegoro University, 3rd Floor Building A, JL. Prof. Soedarto, SH, Tembalang, Semarang 50232
Indonesia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijp.IJP_655_18

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Valproic acid (VA) is the antiepileptic, antimigraine and anti-mental disturbances agent. The use of VA is correlated to metabolic rearrangements including changes of lipoproteins; however, these effects still in debate. Herewith we analyze the effect of long-term VA treatment in the level of total cholesterol among adult. Sixty (30 case groups and 30 control groups) participants were asked for venous blood collection to examine the level of total cholesterol by enzymatic cholesterol oxidase phenol 4-aminoantipyrine peroxidase. The relationship of the long-term VA treatment and the level of total cholesterol was obtained from the analysis using the logistic regression analysis. Our analysis depicts that there is a relationship between the long-term VA treatment and the level of total cholesterol (P=0.024, odds ratio 0.272, 95% confidence interval 0.088–0.844). in conclusion, the long-term VA treatment reduces the level of total cholesterol in adult.






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