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 SHORT COMMUNICATION
Year : 2020  |  Volume : 52  |  Issue : 2  |  Page : 130-133

Bioactivities of 7'-ethoxy-trans-feruloyltyramine from Portulaca oleracea L. and its metabolism in rats using ultra-high-performance liquid chromatography electrospray coupled with quadrupole time-of-flight mass spectrometry


1 Department of Cardiology, School of the First Clinic, Liaoning University of Traditional Chinese Medicine, Shenyang, China
2 Department of Pharmaceutical Analysis, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, China

Correspondence Address:
Guanlin Yang
Department of Cardiology, School of the First Clinic, Liaoning University of Traditional Chinese Medicine, Shenyang, 110847
China
Xixiang Ying
Department of Pharmaceutical Analysis, School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 116600
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijp.IJP_171_18

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This research aims to study the antioxidation and anticholinesterase activities of 7'-ethoxy-trans-feruloyltyramine (ETFT), which was an alkaloid isolated from Portulaca oleracea for the first time. Furthermore, its main metabolites and metabolic pathways in rats were also explored. The antioxidation and anticholinesterase effects of ETFT were, respectively, examined using 1,1-diphenyl-2-picrylhydrazyl assay and modified Ellman's method. The results showed that ETFT exhibited both the good antioxidant and anticholinesterase effects. Its main metabolites in rats were implemented, and nine metabolites were finally found in the rat's plasma and urine, including the oxidation, reduction, hydrolysis, glucuronidation, sulfation, and glutathionylation process.






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