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 DRUG WATCH
Year : 2019  |  Volume : 51  |  Issue : 6  |  Page : 410-412

Clozapine-induced seizure


Department of Psychiatry, Lokopriya Gopinath Bordoloi Regional Institute of Mental Health, Tezpur, Assam, India

Correspondence Address:
Dr. Ankur Jyoti Borah
LGBRIMH, Tezpur, Assam
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijp.IJP_403_18

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There are very few reports which suggest an association between antipsychotic clozapine low dose and seizure. We report a case in which intial titration of low dose clozapine developed seizure. A 42-year-old female who did not have any history of seizure and had normal blood parameters and normal computed tomography brain at the baseline developed seizure while on clozapine 300 mg/day. Reduction of the dose of clozapine to 250 mg/day led to the return to baseline, with having another episode of seizure on again increasing the dose of clozapine, requiring tablet haloperidol 10 mg/day as an add-on therapy for normalization of behavioral problems. Later, clozapine was maintained on 250 mg/day, with no recurrence of seizure episodes. To conclude, this case report suggests that clozapine can rarely lead to seizure during the initial phase of titration of treatment.






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