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 RESEARCH ARTICLE
Year : 2018  |  Volume : 50  |  Issue : 2  |  Page : 75-83

Pharmacokinetics and bioavailability of chromium malate and its influence on trace metals absorption after oral or intravenous administration


1 Department of Environmental Engineering, School of the Environment and Safety Engineering, Institute of Environmental Health and Ecological Security, Jiangsu, China
2 Department of Food Science, School of Food and Biological Engineering, Jiangsu University, Jiangsu, China
3 Department of Applied Chemistry, School of Chemistry and Chemical Engineering, Jiangsu University, Jiangsu, China
4 Department of Basic Medicine, School of Medical Science and Laboratory Medicine, Jiangsu University, Jiangsu, China

Correspondence Address:
Prof. Liuqing Yang
School of Chemistry and Chemical Engineering, Jiangsu University, 301 Xuefu Rd, 212013 Zhenjiang, Jiangsu
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijp.IJP_505_17

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OBJECTIVES: In our preliminary study, chromium malate could decrease the blood glucose level in mice with diabetes and exhibits good benefits in treating glycometabolism and adipose metabolization obstacle in rats with type 2 diabetes. This study was aimed at assessing the pharmacokinetics and bioavailability of chromium malate and influence on trace metals absorption in rats. METHODS: BAPP 2.3 pharmacokinetic calculating program (China Pharmaceutical University Medicine Center) was used to calculate the pharmacokinetic parameters. Models of type 2 diabetic mellitus rats were applied to analyzed Ca, Mg, Fe, Cu, and Zn contents. RESULTS: The results showed that mean retention time (MRT) in chromium malate group was significantly prolonged and the area under the curve (AUC) and relative bioavailability of chromium malate (male) group were significant increase compared to chromium picolinate group. The serum Ca, Mg, Fe, Cu, and Zn contents in chromium malate (at doses of 15 and 20 μg Cr/kg bw) groups were significantly increased compared to control group, chromium trichloride group, and chromium picolinate group in type 2 diabetes mellitus rats. CONCLUSIONS: Those results indicated that chromium malate can significantly prolong MRT and increase AUC (male). Moreover, chromium malate is more effective at treating increased serum Ca, Mg, Fe, Cu, and Zn contents compared to chromium trichloride and chromium picolinate.






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