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Year : 2017  |  Volume : 49  |  Issue : 2  |  Page : 145-154

Current advances in transdermal delivery of drugs for alzheimer's disease


1 Department of Pharmacy, Ho Chi Minh City University of Technology, Ho Chi Minh City, Vietnam; Department of BionanoTechnology, Gachon Medical Research Institute, Gachon University, Seongnam, Korea
2 Department of BionanoTechnology, Gachon Medical Research Institute, Gachon University, Seongnam, Korea; Department of Food Technology, Ho Chi Minh City University of Food Industry, Ho Chi Minh City, Vietnam
3 Vietnam Sports Hospital, Ministry of Culture, Sports and Tourism, Nam Tu Liem District, Hanoi City, Vietnam

Correspondence Address:
Tuong Kha Vo
Vietnam Sports Hospital, Ministry of Culture, Sports and Tourism, Do Xuan Hop Road, My Dinh I Ward, Nam Tu Liem District, Hanoi City
Vietnam
Vo Van Giau
Department Technology, Ho Chi Minh City University of Food Industry, 140 Le Trong Tan, Tan Phu District, Ho Chi Minh City

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.208143

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Alzheimer's disease (AD) is a common, progressive, fatal neurodegenerative disorder, which will play an increasingly important role both socially and financially in the aging populations. Treatments for AD show modest improvements in cognition and global functioning among patients. Furthermore, the oral administration of treating AD has had some drawbacks that decrease the medication adherence and efficacy of the therapy. Transdermal drugs are proposed as an alternative remedy to overcome the disadvantages of current pharmaceutical dosage options for this chronic disorder. They could have different strengths, such as offering a stable diffusion of active substance, avoiding the first pass metabolism, and reducing system adverse reactions. This article reviews the technical principles, novel techniques of transdermal delivery drug, and prospects for future development for the management of cognitive and behavioral dysfunctions in AD patients.






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