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 DRUG WATCH
Year : 2017  |  Volume : 49  |  Issue : 1  |  Page : 130-131

Chronic administration of phenytoin and pleomorphic adenoma: A case report and review of literature


1 Department of Pharmacology, All Institute of Medical Sciences, New Delhi, India
2 Department of Pharmacology, LHMC, New Delhi, India

Correspondence Address:
Vikas Maharshi
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.201018

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Adverse drug effects that are uncommon or appear only on chronic administration of a drug may not be detected in clinical trials. This explains the need of strict post-marketing vigilance on drug use. Phenytoin administration has been shown in the literature to be associated with development of neoplasia (benign/malignant). In our knowledge current work represents the first case of pleomorphic-adenoma of sub-mandibular salivary gland developed following chronic phenytoin use. A 40 year old male having a history of head trauma twenty years back, had been on tablet phenytoin 100 mg thrice daily since then. One year back he noticed a small swelling in left sub-mandibular region and gradually increasing in size. FNAC and CECT revealed the diagnosis of pleomorphic-adenoma of sub-mandibular salivary gland. Other causes were ruled out. Surgical excision was performed successfully and continuing follow-up with no recurrence at the end of 6 months. Histo-pathogical examination of the tissue did not show any malignant changes.






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