| RESEARCH ARTICLE
|Year : 2016 | Volume
| Issue : 3 | Page : 292-297
Weekly injection of histaglobulin produces long-term remission in chronic urticaria: A prospective clinical study
Gurumoorthy Rajesh1, Subramaniam Keerthi1, Kaliaperumal Karthikeyan1, Murugan Venkatesan2
1 Department of Dermatology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India
2 Department of Community Medicine, Sri Manakula Vinayagar Medical College and Hospital, Puducherry, India
Objective: Treatment of chronic urticaria (CU) can be difficult in many patients. Achieving long-term remission and reducing the requirement of antihistamines are vital in CU. The objective of this study was to assess the effectiveness of injection histaglobulin, a complex of histamine and human immunoglobulin, in producing relief in patients with CU.
Materials and Methods: Fifty-one patients with CU were enrolled into this prospective clinical study. Patients were administered 1 ml of injection histaglobulin subcutaneous for 8 consecutive weeks. They were also prescribed tablet levocetirizine 5 mg to be taken when required (but not more than the permitted dosage). Efficacy was assessed using urticaria activity score (UAS) which has a maximum score of 33/day, during each weekly visit. Final assessment was done after 24 weeks.
Results: Twenty-nine patients had completed the entire 8-week drug regimen. Mean basal UAS was 18.9 ± 6.3 and it reduced to 80.4% by 8 weeks. The angioedema sub-score reduced by 89.8%. Anti-histamine pill burden also reduced significantly. By 24 weeks of starting the therapy, 23 patients (45%) had attained complete remission. No adverse effects to the drug were observed.
Conclusions: Histaglobulin was found to be effective in producing long-term remission and it reduced the antihistamine requirement as well. Thus, it can serve as an effective alternative to existing treatment modalities.
Dr. Gurumoorthy Rajesh
Department of Dermatology, Sri Manakula Vinayagar Medical College and Hospital, Puducherry
Source of Support: None, Conflict of Interest: None
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