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 RESEARCH ARTICLE
Year : 2016  |  Volume : 48  |  Issue : 3  |  Page : 286-291

The antidepressant- and anxiolytic-like activities of new xanthone derivative with piperazine moiety in behavioral tests in mice


1 Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Krakow, 44-101 Gliwice, Poland
2 Institute of Automatic Control, Faculty of Automatic Control, Electronics and Computer Science, Silesian University of Technology, 44-101 Gliwice, Poland
3 Department of Bioorganic Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Krakow, 44-101 Gliwice, Poland

Correspondence Address:
Dr. Karolina Pytka
Department of Pharmacodynamics, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Krakow, 44-101 Gliwice
Poland
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.182872

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Objectives: Xanthones are flavonoids with numerous activities, including antioxidant, antidepressant., or anxiolytic-like. Therefore, the aim of our study was to determine antidepressant- and anxiolytic-like properties of four xanthone derivatives (3-chloro-5-[(4-methylpiperazin-1-yl)methyl]-9H-xanthen-9-one dihydrochloride [HBK-5], 6-methoxy-2-[(4-methylpiperazin-1-yl) methyl]-9H-xanthen-9-one dihydrochloride, 2-[(4-benzylpiperazin-1-yl) methyl]-6-methoxy-9H-xanthen-9-one dihydrochloride, 2-{[4-(2-methoxyphenyl) piperazin-1-yl] methyl}-9H-xanthen-9-one hydrochloride), as well as the influence on cognitive and motor function of active compounds, using animal models. Materials and Methods: To determine the antidepressant-like activity, we used forced swim test (FST) and tail suspension test (TST) in mice. We evaluated anxiolytic-like properties in the four-plate test in mice. We studied the influence on cognitive and motor function in passive avoidance step.through and chimney tests, respectively. Results: The antidepressant-like activity (in both FST and TST) showed only HBK-5. Moreover, the compound was also active in the four-plate test, which suggests that it possessed anxiolytic-like properties. HBK-5 did not cause any cognitive and motor deficits in mice at antidepressant- and anxiolytic-like doses. Conclusions: HBK-5 may have potential in the treatment of depression or anxiety disorders, but this issue needs further studies.






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