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 DRUG WATCH
Year : 2016  |  Volume : 48  |  Issue : 1  |  Page : 86-87

Pure red cell aplasia due to azathioprine therapy for Crohn's disease


1 Department of Gastroenterology and Hepatology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India
2 Medical Student, CHRU Lille, Faculty Henri Warembourg, University of Lille2, Lille, France

Correspondence Address:
C Ganesh Pai
Department of Gastroenterology and Hepatology, Kasturba Medical College, Manipal University, Manipal, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.174569

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Various mechanisms contribute to anemia in inflammatory bowel diseases (IBD), drug-related causes being less frequent. The hematological and other adverse events of azathioprine (AZA) therapy are well documented, but drug-associated pure red cell aplasia (PRCA) is an uncommon event. We hereby describe two cases of AZA-associated PRCA in patients with Crohn's disease. The diagnosis was supported by pathological reports, and prompt hematological recovery was seen with discontinuation of the offending drug. This report highlights the need to consider this rare entity in IBD patients in appropriate settings and for adopting adequate precautionary measures.






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