| SHORT COMMUNICATION
|Year : 2015 | Volume
| Issue : 5 | Page : 555-559
Maxcal-C (a polyherbal formulation) prevents ovariectomy-induced osteoporosis in rats
Rajesh A Maheshwari1, Falak Dhakwala1, R Balaraman1, Avinash K Seth1, Hardik Soni2, Ghanshyam Patel2
1 Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Gujarat, India
2 Vasu Research Centre (A Division of Vasu Healthcare Pvt. Ltd.), Vadodara, Gujarat, India
Objectives: The aim of the present study was to investigate the anti-osteoporotic activity of Maxcal-C in ovariectomy (OVX)-induced osteoporosis in rats.
Materials and Methods: Sham-operated control rats were designated as Group I; Group II animals served as OVX control; Group III OVX control rats treated with Calcium Sandoz (50 mg/kg, p.o.); Group IV and V OVX control rats treated with Maxcal-C (250 and 500 mg/kg, p.o.), respectively. All the aforementioned treatments were given for four weeks after the development of osteoporosis. At the end of the treatment, serum biochemical parameters such as serum calcium and alkaline phosphate were measured. After sacrificing the animals, femoral bone parameters with histology, body weight, and bone breaking strength of 5th lumbar vertebra were measured.
Results: The treatment with Maxcal-C showed a significant improvement in serum biochemical, femoral bone parameters, and bone breaking strength of 5th lumbar vertebra with histopathological changes.
Conclusion: The finding of the present study indicates that Maxcal-C showed a potential anti-osteoporotic activity. These results support the traditional use of Maxcal-C in the treatment of osteoporosis.
Dr. Rajesh A Maheshwari
Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Gujarat
Source of Support: None, Conflict of Interest: None
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