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 DRUG WATCH
Year : 2015  |  Volume : 47  |  Issue : 3  |  Page : 334-335

A case of early detection of bisphosphonate-related osteonecrosis of the jaw


1 Department of Pharmacy, Kuwana West Medical Center, Kuwana, Japan
2 Department of Orthopaedic Surgery, Kuwana West Medical Center, Kuwana, Japan

Correspondence Address:
Dr. Miyu Mori
Department of Pharmacy, Kuwana West Medical Center, Kuwana
Japan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.157137

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Osteonecrosis of the jaws is an adverse reaction associated with the use of bisphosphonates. Although the diagnosis of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is based on symptomatology, it is often detected late because the patients become symptomatic only after osteonecrosis is well established. We describe a case of early oral BRONJ detected by magnetic resonance imaging (MRI) accidentally. Head MRI revealed low signal of T1-weight images in left mandibula. Patient had been treated with minodronate for osteoporosis during 18 months. Based on the MRI findings and medication history, early stage BRONJ could be considered. Therefore minodronate was switched to teriparatide. Thereafter mandible pares-thesias, odontalgia and exposed bone were not observed. This case suggests that MRI is useful for the early detection of BRONJ.






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