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 SHORT COMMUNICATION
Year : 2015  |  Volume : 47  |  Issue : 2  |  Page : 215-218

Gamma activity model for treatment-resistant bipolar psychotic mania


Department of? Psychiatry and K. S. Mani Center for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi, Jharkhand, India

Correspondence Address:
Sai Krishna Tikka
Department of? Psychiatry and K. S. Mani Center for Cognitive Neurosciences, Central Institute of Psychiatry, Ranchi, Jharkhand
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.153434

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Objectives: The objective was to investigate the effect of clozapine on spontaneous gamma activity in treatment-resistant bipolar psychotic mania. Methods: Patients with treatment-resistant (TR) bipolar psychotic mania on clozapine monotherapy and nontreatment-resistant bipolar psychotic mania patients receiving lithium were prospectively studied for 6 weeks on severity of psychopathology and 30-49 Hz gamma spectral power. Results: Spectral power significantly increased in the lithium group and decreased in the clozapine group; no within group significant difference found. Conclusions: We propose a model highlighting the role of gamma spectral power and modulations of GABAergic neurotransmission in TR bipolar psychotic mania.






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