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 Table of Contents    
LETTER TO THE EDITOR
Year : 2015  |  Volume : 47  |  Issue : 1  |  Page : 125
 

Cost-effectiveness of the baclofen versus chlordiazepoxide in alcohol withdrawal syndrome


1 Medical Science, Shantou, China
2 Tropical Medicine,Hainan Medical University, Haikou, China

Date of Web Publication30-Jan-2015

Correspondence Address:
Prof. Sim Sai Tin
Medical Science, Shantou
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.150379

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How to cite this article:
Tin SS, Wiwanitkit V. Cost-effectiveness of the baclofen versus chlordiazepoxide in alcohol withdrawal syndrome. Indian J Pharmacol 2015;47:125

How to cite this URL:
Tin SS, Wiwanitkit V. Cost-effectiveness of the baclofen versus chlordiazepoxide in alcohol withdrawal syndrome. Indian J Pharmacol [serial online] 2015 [cited 2019 Dec 9];47:125. Available from: http://www.ijp-online.com/text.asp?2015/47/1/125/150379


Sir,

This letter is in the context to an article published in Indian Journal of Pharmacology in entitled "cost-effectiveness of the baclofen versus chlordiazepoxide in alcohol-withdrawal syndrome." [1] The authors concluded that chlordiazepoxide was more cost-effective than baclofen in the treatment of alcohol withdrawal syndrome. The present data can support the use of these drugs for alcohol withdrawal syndrome. However, as noted by Amato et al. in a meta-analysis, the effect of chlordiazepoxide is yet inconclusive and the adverse effect of these drugs is a matter of concern. [2] The adverse effects of chlordiazepoxide have been well documented. [3] It is reported that chlordiazepoxide is inferior to other drugs such as nifedipine in terms of adverse effects, when used for managing alcohol withdrawal syndrome, [4] Considering the study by Reddy et al., [1] the drug merits further evaluation.

 
  References Top

1.
Reddy VK, Girish K, Lakshmi P, Vijendra R, Kumar A, Harsha R. Cost-effectiveness analysis of baclofen and chlordiazepoxide in uncomplicated alcohol-withdrawal syndrome. Indian J Pharmacol 2014;46:372-7.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Amato L, Minozzi S, Davoli M. Efficacy and safety of pharmacological interventions for the treatment of the Alcohol Withdrawal Syndrome. Cochrane Database Syst Rev 2011;CD008537.  Back to cited text no. 2
    
3.
Benor D. Side effect of chlordiazepoxide. J Clin Pharmacol J New Drugs 1967;7:180.  Back to cited text no. 3
[PUBMED]    
4.
Samochowiec J, Fabiañczyk K, Reszczyñski R, Czopek I, Pe³ka-Wysiecka J, Horodnicki JM. The effect of nifedipine and chlordiazepoxide on alcohol withdrawal syndrome. Psychiatr Pol 1996;30:307-20.  Back to cited text no. 4
    




 

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