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 DRUG WATCH
Year : 2015  |  Volume : 47  |  Issue : 1  |  Page : 121-122

Reversible bilateral ototoxicity in a patient with chronic hepatitis B during peginterferon alpha-2a treatment


Department of Infectious Diseases and Clinical Microbiology, Sakarya University Faculty of Medicine, Sakarya, Turkey

Correspondence Address:
Dr. Hasan Tahsin Gozdas
Department of Infectious Diseases and Clinical Microbiology, Sakarya University Faculty of Medicine, Sakarya
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.150377

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Peginterferon alpha-2a (PEG IFN α-2a) is frequently used in chronic hepatitis B (CHB)treatment. Numerous adverse events can be noted during this therapy such as flu-like disease, rash, weight loss and depression. However, PEG IFN α-2a related ototoxicity seems to be an uncommon entity. Ototoxicity can be detected objectively by audiometry. In this paper, we present a case of CHB who developed reversible bilateral ototoxicity during PEG IFN α-2a treatment. Due to ototoxicity detected objectively by audiogram, treatment was ceased at sixth month and ototoxicity completely recovered one month after stopping the drug.






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