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 DRUG WATCH
Year : 2014  |  Volume : 46  |  Issue : 6  |  Page : 649-650

Autoimmune hepatitis as an adverse effect of long-term methotrexate therapy


1 Department of Pharmacology, School of Medecine of Sfax, Tunisia
2 Department of Rheumatology, CHU Hedi Chaker Sfax, Tunisia

Correspondence Address:
Kamilia Ksouda
Department of Pharmacology, School of Medecine of Sfax
Tunisia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.144940

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Methotrexate (MTX) is one of the most commonly used medicines in the treatment of psoriatic arthritis. The drug can produce steatosis and cirrhosis. Autoimmune hepatitis is a rare and serious adverse effect. We describe the case of a 53-year-old woman who developed autoimmune hepatitis after a long-term use of MTX for psoriatic arthritis. Hepatitis was completely resolved 4 months after stopping this drug. The pathophysiologic mechanisms of a drug-induced autoimmunity are unclear and complex. This report confirms the need to monitor liver enzymes carefully in patients using long-term treatment with MTX for psoriasis or rheumatoid arthritis.






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