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 RESEARCH ARTICLE
Year : 2014  |  Volume : 46  |  Issue : 6  |  Page : 639-643

Effect of combination of ketanserin and escitalopram on behavioral anomalies after olfactory bulbectomy: Prediction of quick onset of antidepressant action


1 Department of Pharmacology, Novel Drug Discovery and Development, Lupin Ltd, Research Park, Nanded Village, Pune, Maharashtra, India
2 Department of Pharmacy, FD-III, Birla Institute of Technology and Science, Pilani, Rajasthan, India

Correspondence Address:
Dilip K Pandey
Department of Pharmacology, Novel Drug Discovery and Development, Lupin Ltd, Research Park, Nanded Village, Pune, Maharashtra
India
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Source of Support: Author would also like to thank the Council of Scientific and Industrial Research for partly funding this work, Conflict of Interest: None


DOI: 10.4103/0253-7613.144935

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Objectives: Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressant drugs. The addition of low dose of 5-hydroxytryptamine type 2A enhances the therapeutic effect of SSRIs. The purpose of the present studies was to test the effects of combined treatment of a low dose of ketanserin (KET) and escitalopram (ESC) on behavioral anomalies occurring after olfactory bulbectomy (OBX). Materials and Methods: Chronic Depression was induced by OBX as shown in behavioral tests such as Open field, social interaction, and hyperemotionality tests. Acute and chronic treatment effect of KET, ESC, and combination was administered to the OBX rats. Results: Chronic (14 days) treatment with KET (1 mg/kg) or ESC (10 mg/kg) alleviated the behavioral anomalies of olfactory bulbectomized rats in modified open field exploration, social interaction, hyperemotionality.  When KET treatment was combined with ESC, a short duration regimen (7 days) was sufficient to reverse the bulbectomy-induced anomalies. Conclusion: The combination therapy as a likely strategy to achieve an early-onset of antidepressant action.






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