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 SHORT ARTICLE
Year : 2014  |  Volume : 46  |  Issue : 2  |  Page : 216-221

Anti-fibrosis effects of Huisheng oral solution in CCl 4 -induced hepatic fibrosis in rat


1 Department of Infectious Disease, Anhui Provincial Hospital, Hefei, China
2 Department of Neurology, Anhui Provincial Hospital, Hefei, China
3 Department of Respiratory and Critical Medicine, Zhengzhou University, China
4 Central Lab, Anhui Provincial Hospital, Hefei, China

Correspondence Address:
Rentao Gao
Department of Infectious Disease, Anhui Provincial Hospital, Hefei
China
Wenting Li
Department of Infectious Disease, Anhui Provincial Hospital, Hefei
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.129323

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Aim: Some gradient of Huisheng oral solution (HOS) has been reported to have anti-fibrosis activity. This study was designed to investigate whether HOS could inhibit liver fibrosis and to elucidate its molecular mechanism of action. Materials and Methods: Hepatic fibrosis model in rat was induced by subcutaneous injection of CCl 4 . Rats in the treatment group were administrated with HOS intragastrically. Hematoxylin and eosin (H and E) staining and Masson's trichrome staining were used to examine the changes in liver pathology. Levels of ALT, AST, LDH, hyaluronic acid (HA) and laminin (LN) in serum and hydroxyproline (Hyp) in liver were detected by biochemical examination and radioimmunoassay, respectively. The expression and distribution of Smad3, TGF-β1, α-SMA and TIMP-1 were observed and the active TGF-β1 was tested. Results: Our data demonstrated that HOS alleviated CCl 4 -induced collagen deposition in liver tissue, improved liver condition and liver function in rats. HOS also significantly reduced the expression and distribution of Smad3, TGF-β1, α-SMA and TIMP-1 as well as decreased active TGF-β1. Conclusions: This study revealed that HOS attenuates the development of liver fibrosis through suppressing the TGF-β1 pathway. It provides us a new approach to treatment of liver fibrosis.






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