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 DRUG WATCH
Year : 2013  |  Volume : 45  |  Issue : 6  |  Page : 631-633

Pott's disease and hypercalcemia in a patient with rheumatoid arthritis receiving methotrexate monotherapy


1 Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, Fatih, Istanbul 34093, Turkey
2 Family Medicine Clinic, Recep Tayyip Erdogan University, Faculty of Medicine, 53100 Rize, Turkey

Correspondence Address:
Mehmet Zorlu
Internal Medicine Clinic, Bezmialem Vakif University, Faculty of Medicine, Fatih, Istanbul 34093
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.121385

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Methotrexate (MTX) may have adverse effects on multiple organs and system. A few cases of pulmonary tuberculosis in-patients with rheumatoid arthritis (RA) while receiving MTX monotherapy has been reported in the literature. We submit a case of vertebral tuberculosis with hypercalcemia in a patient receiving MTX monotherapy. Patient with RA taking MTX for 15 years developed pancytopenia, skin necrosis, tuberculous spondylodiscitis and hypercalcemia. The present case showed adverse effects of MTX therapy may occur even after years of continuous treatment. Due to pancytopenia in older patients, life-threatening tuberculosis at unusual sites may develop.






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