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 RESEARCH ARTICLE
Year : 2013  |  Volume : 45  |  Issue : 6  |  Page : 575-580

Neuroprotective activity of gossypin from Hibiscus vitifolius against global cerebral ischemia model in rats


1 Department of Pharmacology, Hanagal Shri Kumareshwar College of Pharmacy, Bagalkot, Karnataka, India
2 Pharmacognosy and Phytochemistry Division, College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, India
3 CDSCO, Subzonal Office, Ahmedabad, Gujarat, India
4 Center of Biotechnology, Institute of Science and Technology, JNT University, Hyderabad, Andhra Pradesh, India

Correspondence Address:
V M Chandrashekhar
Department of Pharmacology, Hanagal Shri Kumareshwar College of Pharmacy, Bagalkot, Karnataka
India
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Source of Support: This study was supported by a research grant VGST/P-8/CISE/2011-2/1151 from Vision Group on Science and Technology, Department of IT, BT, Science and Technology, Govt. of Karnataka, Bangalore, Karnataka (V.M.C)., Conflict of Interest: None


DOI: 10.4103/0253-7613.121367

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Objectives: The objective of this study is to evaluate the neuroprotective effect of gossypin (isolated from Hibiscus vitifolius) against global cerebral ischemia/reperfusion (I/R) injury-induced oxidative stress in rats. Materials and Methods: Sprague Dawlet rats of wither gender were used in the study. Evaluation of cerbroprotective activity of bioflavonoid gossypin (in 5, 10 and 20 mg/kg oral doses) isolated from H. vitifolius was carried out by using the global cerebral I/R model by bilateral carotid artery occlusion for 30 min, followed by 24 h reperfusion. The antioxidant enzymatic and non-enzymatic levels were estimated along with histopathological studies. Result: Gossypin showed dose-dependent neuroprotective activity by significant decrease in lipid peroxidation (P < 0.001) and increase in the superoxide dismutase, catalase, glutathione and total thiol levels in gossypin treated groups when compared to control group. Cerebral infarction area was markedly reduced in gossypin treated groups when compared to control group. Conclusion: Gossypin showed potent neuroprotective activity against global cerebral I/R injury-induced oxidative stress in rats.






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