IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 2164 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2838    
    Printed42    
    Emailed1    
    PDF Downloaded101    
    Comments [Add]    

Recommend this journal

 

 SHORT COMMUNICATION
Year : 2013  |  Volume : 45  |  Issue : 5  |  Page : 517-521

Histological changes in the liver of fetuses of pregnant rats following citalopram administration


1 Department of Biology, Islamic Azad University, Damghan Branch, Damghan; Department of Animal Biology, Biological Science Faculty, Kharazmi University, Tehran, Iran
2 Department of Animal Biology, Biological Science Faculty, Kharazmi University, Tehran, Iran
3 Departments of Biology, Islamic Azad University, Damghan Branch, Damghan, Iran
4 Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran

Correspondence Address:
Zohreh Mohammadi
Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.117726

Rights and Permissions

Objective: Depression is a dilapidating disorder, which may occur during pregnancy. Citalopram is an antidepressant drug often prescribed to pregnant women. The purpose of the present study is to determine whether maternal administration of citalopram affects fetal liver histology. Materials and Methods: Pregnant Wistar albino rats were treated with citalopram (10 or 20 mg/kg/day). A control group received no treatment. Rat fetal liver samples were obtained on day 18 of gestation and evaluated morphologically and histologically. Results: Statistical evaluation of data showed that there were no differences in liver weight and relative liver weight between control and citalopram treatment groups. Liver histology changes (such as increases in the number of Kupffer cells and lymphocytes) were seen in the fetuses of the group receiving a high dose of citalopram during gestation. Degeneration of hepatocytes was not seen and the megakaryocyte number did not change significantly in the citalopram treated groups. Conclusion: This study showed that citalopram administration during gestation may have some adverse effects on the phagocytic cell population in the fetal liver of rats.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow