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 RESEARCH ARTICLE
Year : 2013  |  Volume : 45  |  Issue : 5  |  Page : 479-482

Ethanolic extract of Piper betle Linn. leaves reduces nociception via modulation of arachidonic acid pathway


Department of Pharmacology, Institute of Postgraduate Medical Education & Research, Kolkata, West Bengal, India

Correspondence Address:
Mitali Chatterjee
Department of Pharmacology, Institute of Postgraduate Medical Education & Research, Kolkata, West Bengal
India
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Source of Support: The work received financial assistance from the Department of Biotechnology and Board of Research in Nuclear Sciences, Govt. of India., Conflict of Interest: None


DOI: 10.4103/0253-7613.117766

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Objectives: The objective of this study was to evaluate the peripheral analgesic effect of Piper betle leaf extract (PBE) along with establishing its putative mechanism of action. Materials and Methods: Male Swiss albino mice after pre-treatment (1 h) with different doses of PBE were injected 0.8% (v/v) acetic acid i.p.; the onset and number of writhes were noted up to 15 min. To evaluate the mechanism of action, the murine peritoneal exudate was incubated with PBE for 1 h, followed by exposure to arachidonic acid (AA) and generation of reactive oxygen species (ROS) was measured by flow cytometry using 2',7'-dichlorodihydrofluorescein diacetate. Results: PBE in a dose dependent manner significantly reduced acetic acid induced writhing response in mice (P < 0.001). In peritoneal exudates, PBE significantly inhibited AA induced generation of ROS, P < 0.01. Conclusions: The present study indicates that PBE has promising analgesic activity, worthy of future pharmacological consideration.






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