IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 2161 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3213    
    Printed38    
    Emailed2    
    PDF Downloaded166    
    Comments [Add]    
    Cited by others 1    

Recommend this journal

 

 RESEARCH ARTICLE
Year : 2013  |  Volume : 45  |  Issue : 4  |  Page : 395-398

Antioxidative effects of hesperetin against lead acetate-induced oxidative stress in rats


1 Department of Veterinary Medicine, College of Animal Science and Technology, Henan University of Science and Technology, No.70, Tianjin Road, 471003, Luoyang, PR China
2 Department of Veterinary Medicine, College of Veterinary Medicine, Yangzhou University, No.12, East Wenhui Road, 225009, Yangzhou, PR China

Correspondence Address:
Zijun Yang
Department of Veterinary Medicine, College of Animal Science and Technology, Henan University of Science and Technology, No.70, Tianjin Road, 471003, Luoyang
PR China
Login to access the Email id

Source of Support: The research fund for doctor of Henan University of Science and Technology (09001489)., Conflict of Interest: None


DOI: 10.4103/0253-7613.115015

Rights and Permissions

Objectives: Oxidative stress with subsequent lipid peroxidation (LP) has been suggested as a mechanism for lead-induced toxicity. The current study was carried out to evaluate antioxidant activity of hesperetin against lead acetate-induced oxidative stress. Materials and Methods: The male rats were treated with hesperetin in combination with lead acetate (500 mg/L). Results: The results indicated that hesperetin alone did not induce any significant changes in the biochemistry of serum, liver, and kidney tissues. On the other hand, lead-induced oxidative stress as indicated by significant changes in serum biochemical parameters, including increased lipid peroxide and decreased reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels in liver and kidney tissues. Hesperetin succeeded in improving these biochemical parameters towards the normal values of control. Conclusions: It suggests that hesperetin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in liver and kidney of rats.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow