IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1254 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2187    
    Printed62    
    Emailed1    
    PDF Downloaded104    
    Comments [Add]    
    Cited by others 2    

Recommend this journal

 

 SHORT COMMUNICATION
Year : 2013  |  Volume : 45  |  Issue : 3  |  Page : 283-285

Anti-thrombotic activity of DT-13, a saponin isolated from the root tuber of Liriope muscari


1 Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing; Lianyungang TCM Branch, Jiangsu Union Vocational Technical Institute, Lianyungang; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
2 Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China
3 Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, China

Correspondence Address:
Boyang Yu
Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing
China
Login to access the Email id

Source of Support: This work was supported by the Major National Science and Technology Project of China for Significant New Drugs Development (No. 2009ZX09103-308 and 2012ZX09102201-015), and A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions. (We have described these foundations in acknowledgements)., Conflict of Interest: No


DOI: 10.4103/0253-7613.111896

Rights and Permissions

Objective: To investigate the anti-thrombotic activity of DT-13 in experimental animal models. Materials and Methods: The anti-thrombotic activity of DT-13 was evaluated by measuring the thrombus induced by inferior vena cava (IVC) ligation in mice and rats. The anti-thrombotic mechanism of DT-13 was investigated by assessing the mRNA expression levels of interleukin-6 (IL-6) and tissue factor (TF) in rat IVC tissue around thrombus. Results: DT-13 markedly inhibited thrombosis induced by IVC ligation for 6 h in mice (2.0 and 4.0 mg/kg, p.o.) and for 18 h in rats (1.4 mg/kg, p.o.). Furthermore, DT-13 down-regulated the increased mRNA expression levels of IL-6 and TF in rats. Conclusions: DT-13 has an anti-thrombotic activity due to down-regulation of the increased mRNA expression levels of IL-6 and TF.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow