IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1510 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2308    
    Printed55    
    Emailed1    
    PDF Downloaded310    
    Comments [Add]    

Recommend this journal

 

 RESEARCH ARTICLE
Year : 2013  |  Volume : 45  |  Issue : 3  |  Page : 232-236

Protective effect of Hygrophila spinosa against cisplatin induced nephrotoxicity in rats


1 Department of Pharmacology, AISSMS College of Pharmacy, Pune; KYDSCT's College of Pharmacy, Sakegaon, Bhusawal, India
2 Indus biotech Pvt. Ltd. Pune, India
3 Department of Pharmacology, AISSMS College of Pharmacy, Pune, India

Correspondence Address:
Kundan G Ingale
Department of Pharmacology, AISSMS College of Pharmacy, Pune; KYDSCT's College of Pharmacy, Sakegaon, Bhusawal
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.111909

Rights and Permissions

Objective: To evaluate the nephroprotective effect of methanolic extract of Hygrophila spinosa (HSME) (Acanthaceae) in (CP)-induced acute renal failure in rats. Materials and Methods: HSME (250 mg/kg and 500 mg/kg body weight), were administered orally to male wistar albino rats.CP was used to induce acute renal failure. The parameters studied included blood urea and serum creatinine and malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), superoxide dismutase (SOD) and GSH peroxidase activities. Histopathological examination was also carried out. Results: The results revealed that HSME pretreatment signiϋcantly reduced blood urea and serum creatinine levels elevated by CP administration. Furthermore, HSME signiϋcantly attenuated CP-induced increase in MDA and decrease in reduced GSH, and CAT and SOD and GSH peroxidase activities in renal cortical homogenates. Additionally, histopathological examination showed that HSME markedly ameliorated CP-induced renal tubular necrosis. Conclusion: The results indicate that the aerial parts of H. spinosa are endowed with nephroprotective activity.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow