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 RESEARCH ARTICLE
Year : 2013  |  Volume : 45  |  Issue : 3  |  Page : 223-226

Comparative evaluation of aqueous and plasma concentration of topical moxifloxacin alone and with flurbiprofen in patients of cataract


1 Department of Pharmacology, Malda Medical College, Malda, India
2 Department of Ophthalmology, R.G. Kar Medical College, Kolkata, India
3 Department of Pharmacology, Burdwan Medical College, Burdwan, India
4 Department of Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences (WBUAFS), Kolkata, India
5 Department of Pharmacology, R.G. Kar Medical College, Kolkata, India

Correspondence Address:
Sujash Halder
Department of Pharmacology, Malda Medical College, Malda
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.111900

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Objectives: To determine the aqueous and plasma concentrations of moxifloxacin administered topically alone and with flurbiprofen in patients undergoing cataract surgery. Materials and Methods: A total of 50 subjects scheduled for routine cataract surgery were randomly allocated to two groups (n = 25 each). Group-1 patients were treated with topical moxifloxacin alone: One drop 6 times/day for 3 days before surgery and one drop 4 times on the day of surgery: Group-2 patients were treated with topical moxifloxacin as in Group-1 and with topical flurbiprofen: One drop 4 times/day for 3 days before and on the day of surgery. The interval between two drugs was 30 min for last 3 days and 15 min on the day of surgery. Last dose was administered 1 h before aqueous humor and blood sampling for both the groups. The antibiotic concentration in aqueous humor and plasma were determined by using high performance liquid chromatography. Results: The mean concentration of moxifloxacin in aqueous humor was 1.71 ± 0.82 mg/ml in Group-1 and 2.39 ± 1.34 mg/ml in Group-2. Concentrations of moxifloxacin in aqueous humor were significantly higher in Group-2 than that of Group-1. Conclusion: Flurbiprofen may increase the concentration of moxifloxacin in aqueous humor.






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