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Year : 2012  |  Volume : 44  |  Issue : 4  |  Page : 516-518

Calcium antagonistic activity of Bacopa monniera in guinea-pig trachea


Department of Pharmacology, HEJ Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological Sciences, University of Karachi, Karachi - 75270, Pakistan

Correspondence Address:
Shabana Channa
Department of Pharmacology, HEJ Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research International Center for Chemical and Biological Sciences, University of Karachi, Karachi - 75270
Pakistan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.99336

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Objective: To demonstrate the calcium antagonistic property of ethanol extract of Bacopa monniera in guinea-pig trachea. Materials and Methods: The dose response curves of CaCl 2 (1 × 10 -5 to 1 × 10 -1 M) were constructed in the absence and presence of ethanol extract of Bacopa monniera (100, 500 and 700 μg/ml) or nifedipine (1 × 10 -6 M) in guinea-pig trachea in calcium free high K + -MOPS-PSS (3-(N-morpholino)-propanesulphonic acid physiological salt solution). The data was analyzed by ANOVA followed by least significant difference test or by Student's 't' test for unequal variance when appropriate. A probability of at least P < 0.05 was considered statistically significant. Results: The plant extract (500 and 700 μg/ml) significantly (P < 0.05) depressed and shifted the calcium concentration-response curves (1 × 10 -3 - 1 × 10 -1 M) to rightward similar to that of nifedipine. Conclusions: Bacopa monniera extract exhibited calcium channel blocking activity in guinea-pig tracheal smooth muscles that may rationalize its relaxant action on guinea-pig trachea and its traditional use in respiratory disorders.






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