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 SHORT COMMUNICATION
Year : 2012  |  Volume : 44  |  Issue : 4  |  Page : 509-511

Antibacterial activity of the venom of Heterometrus xanthopus


1 Faculty of Health Sciences, Department of Microbiology, Hazara University, Mansehra, Pakistan
2 Department of Global Agriculture, Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan

Correspondence Address:
Nauman Khalid
Department of Global Agriculture, Graduate School of Agriculture and Life Sciences, University of Tokyo
Japan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.99332

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Heterometrus xanthopus (Scorpion) is one of the most venomous and ancient arthropods. Its venom contains anti-microbial peptides like hadrurin, scorpine, Pandinin 1, and Pandinin 2 that are able to effectively kill multidrug-resistant pathogens. The present study was conducted to evaluate the anti-bacterial activity of H. xanthopus venom. Six Gram-positive and Gram-negative bacterial strains were tested against 1/100, 1/10, and 1/1 fractions of distilled water diluted and crude venom. 1/100 and 1/10 dilutions were not successful in any of the six bacterial strains studied while the 1/1 dilution was effective on Bacillus subtilis ATCC 6633, Salmonella typhimurium ATCC 14028, and Pseudomonas aeruginosa ATCC 27853 with highest zone of inhibition were obtained on B. subtilis. Crude venom was effective against Enterococcus faecalis ATCC 14506, B. subtilis, S. typhimurium, and P. aeruginosa. The most effective results were observed on B. subtilis.






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