IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 520 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2589    
    Printed78    
    Emailed4    
    PDF Downloaded299    
    Comments [Add]    
    Cited by others 3    

Recommend this journal

 

 RESEARCH ARTICLE
Year : 2012  |  Volume : 44  |  Issue : 3  |  Page : 304-307

Alcea rosea root extract as a preventive and curative agent in ethylene glycol-induced urolithiasis in rats


1 Pharmacological Research Center of Medicinal Plants and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2 Pharmacological Research Center of Medicinal Plants and Department of Physiology, School of Medicine; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
3 Department of Pathology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

Correspondence Address:
Ziba Rajaei
Pharmacological Research Center of Medicinal Plants and Department of Physiology, School of Medicine; Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad
Iran
Login to access the Email id

Source of Support: Grant from the Council of Research, Mashhad University of Medical Sciences, Conflict of Interest: None


DOI: 10.4103/0253-7613.96298

Rights and Permissions

Introduction: Alcea rosea L. is used in Asian folk medicine as a remedy for a wide range of ailments. The aim of the present study was to investigate the effect of hydroalcoholic extract of Alcea rosea roots on ethylene glycol-induced kidney calculi in rats. Materials and Methods: Male Wistar rats were randomly divided into control, ethylene glycol (EG), curative and preventive groups. Control group received tap drinking water for 28 days. Ethylene glycol (EG), curative and preventive groups received 1% ethylene glycol for induction of calcium oxalate (CaOx) calculus formation; preventive and curative subjects also received the hydroalcoholic extract of Alcea rosea roots in drinking water at dose of 170 mg/kg, since day 0 or day 14, respectively. Urinary oxalate concentration was measured by spectrophotometer on days 0, 14 and 28. On day 28, the kidneys were removed and examined histopathologically under light microscopy for counting the calcium oxalate deposits in 50 microscopic fields. Results: In both preventive and curative protocols, treatment of rats with hydroalcoholic extract of Alcea rosea roots significantly reduced the number of kidney calcium oxalate deposits compared to ethylene glycol group. Administration of Alcea rosea extract also reduced the elevated urinary oxalate due to ethylene glycol. Conclusion: Alcea rosea showed a beneficial effect in preventing and eliminating calcium oxalate deposition in the rat kidney. This effect is possibly due to diuretic and anti-inflammatory effects or presence of mucilaginous polysaccharides in the plant. It may also be related to lowering of urinary concentration of stone-forming constituents.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow