IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 296 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed5735    
    Printed137    
    Emailed1    
    PDF Downloaded566    
    Comments [Add]    
    Cited by others 6    

Recommend this journal

 

 REVIEW ARTICLE
Year : 2012  |  Volume : 44  |  Issue : 3  |  Page : 299-303

Molecular mechanism of alcoholic fatty liver


1 Department of Internal Medicine, University of Nebraska Medical Center; The Liver Study Unit, VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA
2 Department of Internal Medicine; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center; The Liver Study Unit, VA Nebraska-Western Iowa Health Care System, Omaha, NE, USA

Correspondence Address:
Karuna Rasineni
Department of Internal Medicine, University of Nebraska Medical Center; The Liver Study Unit, VA Nebraska-Western Iowa Health Care System, Omaha, NE
USA
Login to access the Email id

Source of Support: Department of Veterans’ Affairs, and the NIH (5RC1 AA019032), Conflict of Interest: None


DOI: 10.4103/0253-7613.96297

Rights and Permissions

Ethanol abuse and chronic ethanol consumption remains a major public health problem and is responsible for a high rate of morbidity. Alcohol-induced fatty liver generally begins as hepatic steatosis, and if the cause persists, this invariably progresses to steatohepatitis and cirrhosis. The original biochemical explanation for an alcoholic fatty liver centered on the ability of ethanol metabolism to shift the redox state of the liver and inhibit fatty acid oxidation. Subsequent studies found repression of fatty acid oxidation and that the induction of lipogenesis can occur in alcoholic conditions. Ethanol activates sterol regulatory element binding protein 1, inducing a battery of lipogenic enzymes. These effects may be due in part to inhibition of AMP-dependent protein kinase, reduction in plasma adiponectin or increased levels of TNF-α the liver. They in turn activate lipogenic pathways and inhibit fatty acid oxidation. Besides the fatty acid synthesis and oxidation, ethanol also alters lipid droplet (LD, the storage form of triglycerides, TG) metabolism in hepatocytes and very low-density lipoprotein (VLDL) secretion from liver. Because steatosis is now regarded as a significant risk factor for advanced liver pathology, an understanding of the molecular mechanisms in its etiology provides new therapeutic targets to reverse the alcoholic fatty liver.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow