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 RESEARCH ARTICLE
Year : 2011  |  Volume : 43  |  Issue : 4  |  Page : 424-428

Influence of Momordica charantia on oxidative stress-induced perturbations in brain monoamines and plasma corticosterone in albino rats


1 Department of Pharmacology, Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa; Department of Pharmacology, St. Peter's Institute of Pharmaceutical Sciences, Warangal, Andhra Pradesh, India
2 Department of Pharmacology, St. Peter's Institute of Pharmaceutical Sciences, Warangal, Andhra Pradesh, India
3 Department of Pharmacology, Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa, India

Correspondence Address:
Ch. Naga Kavitha
Department of Pharmacology, Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa; Department of Pharmacology, St. Peter's Institute of Pharmaceutical Sciences, Warangal, Andhra Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.83114

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Objectives: The objective of this study was to evaluate the antistress activity of Momordica charantia (MC) fruit extract on stress-induced changes in albino rats and also to explore attenuating effects of MC on in vitro lipid peroxidation in rat brain. Materials and Methods: In this study, Wistar albino rats (180-200 g) were used. Plasma corticosterone and monoamines-5-hydroxy tryptamine (5-HT), norepinephrine (NE), epinephrine (E) and dopamine (DA) in cortex, hypothalamus and hippocampus regions of brain were determined in animals under different stressful conditions. Ethanolic fruit extract of MC, at doses of 200 and 400 mg/kg, was used. The oxidative stress paradigms used in in vivo models were acute stress (AS) and chronic unpredictable stress (CUS). Panax quinquefolium (PQ) was used as a standard in in vivo models and ascorbic acid was used as a reference standard in the in vitro method. Results: Subjecting the animals to AS (immobilization for 150 min once only) resulted in significant elevation of plasma corticosterone levels and brain monoamine levels. Pretreatment with MC at doses of 200 and 400 mg/kg p.o. significantly countered AS-induced changes and a similar effect was exhibited by PQ at 100 mg/kg p.o. In the CUS regimen (different stressors for 7 days), plasma corticosterone levels were significantly elevated whereas the levels of 5-HT, NE, E, and DA were depleted significantly. Pretreatment with MC (200 and 400 mg/kg) attenuated the CUS-induced changes in the levels of above monoamines in cortex, hypothalamus, and hippocampus regions of brain and plasma corticosterone in a dose-dependent manner. Furthermore, MC extract (1000-5000 μg/mL) exhibited a significant quenching effect on in vitro lipid peroxidation indicating its strong antioxidant activity which was compared with ascorbic acid. Conclusions: This study reveals the antistress activity of MC as it significantly reverted the stress-induced changes, and the activity might be attributed to its antioxidant activity since stress is known to involve several oxidative mechanisms.






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