IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 72 
Small font sizeDefault font sizeIncrease font size
Navigate Here
  Search
 
  
Resource Links
   Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
   Article in PDF (339 KB)
   Citation Manager
   Access Statistics
   Reader Comments
   Email Alert *
   Add to My List *
* Registration required (free)

 
In This Article
   References

 Article Access Statistics
    Viewed455    
    Printed47    
    Emailed0    
    PDF Downloaded80    
    Comments [Add]    

Recommend this journal

 


 
 Table of Contents    
LETTER TO THE EDITOR
Year : 2011  |  Volume : 43  |  Issue : 3  |  Page : 360-361
 

Authors' reply


Department of Pharmacology, Government Medical College, Miraj, Maharashtra, India

Date of Web Publication24-May-2011

Correspondence Address:
Pramod B Akat
Department of Pharmacology, Government Medical College, Miraj, Maharashtra
India
Login to access the Email id


PMID: 21713053

Get Permissions



How to cite this article:
Akat PB, Bapat TR, Murthy MB, Karande VB, Burute SR. Authors' reply. Indian J Pharmacol 2011;43:360-1

How to cite this URL:
Akat PB, Bapat TR, Murthy MB, Karande VB, Burute SR. Authors' reply. Indian J Pharmacol [serial online] 2011 [cited 2014 Oct 21];43:360-1. Available from: http://www.ijp-online.com/text.asp?2011/43/3/360/81490


Sir,

We thank for the valuable comments [1] on our paper. [2] Our reply to the queries is as follows:

  1. Sample size in our study was calculated by using the formula [3] for sample size estimation for quantitative data and was found adequate. The results of previous study were used for calculations. The power of our study was 90% at 1% level of significance.
  2. We regret the typing error. Please read the range as mild hypertension systolic blood pressure (SBP)/diastolic blood pressure (DBP): 140-159/90-99 mmHg. Moderate hypertension SBP/DBP: 160-179/100-109 mmHg.
  3. Suggestion at 3 is well taken for future studies.
  4. It is clear from the background of our study that the study was planned to focus on advantages of telmisartan over enalapril. Taking this into consideration, the diastolic BP was taken as primary end point and systolic BP was measured simultaneously; therefore, its relevance in the study remains clear. There is strong evidence that systolic BP is a better predictor of cardiovascular events in persons older than 50 years, but diastolic BP is still considered as a better predictor of cardiovascular events than systolic BP [4] in young hypertensives. Therefore, to evaluate the efficacy, telmisartan was compared with enalapril, taking diastolic BP as the primary end point.


 
  References Top

1.Saha L. Comparison of the efficacy and tolerability of telmisartan and enalapril in patients of mild to moderate essential hypertension. Indian J Pharmacol 2011;43:360.  Back to cited text no. 1
  Medknow Journal  
2.Akat PB, Bapat TR, Murthy MB, Karande VB, Burute SR. Comparison of the efficacy and tolerability of telmisartan and enalapril in patients of mild to moderate essential hypertension. Indian J Pharmacol 2010;42:153-6.  Back to cited text no. 2
[PUBMED]  Medknow Journal  
3.Kadam P, Bhalerao S. Sample size calculation. Int J Ayurveda Res 2010;1:55-7.  Back to cited text no. 3
[PUBMED]  Medknow Journal  
4.Perry HM Jr, Miller JP, Baty JD, Carmody SE, Sambhi MP. Pretreatment blood pressure as a predictor of 21-year mortality. Am J Hypertens 2000;13:724-33.  Back to cited text no. 4
[PUBMED]    




 

Top
Print this article  Email this article
 

    

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Medknow