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 SHORT COMMUNICATION
Year : 2010  |  Volume : 42  |  Issue : 6  |  Page : 409-411

Screening of anti-inflammatory and antipyretic activity of Vitex leucoxylon Linn


1 Pranveer Singh Institute of Technology, Kanpur, India
2 Roorki College of Pharmacy, Roorki, Uttar Pradesh, India
3 R.R. College of Pharmacy, Chikbanawara, Bangalore, India

Correspondence Address:
P Shukla
Pranveer Singh Institute of Technology, Kanpur
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.71891

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Objective: This study was designed to evaluate the anti-inflammatory and antipyretic activity of ethyl acetate extract of Vitex leucoxylon Linn. in various animal experimental models. Materials and Methods: Ethyl acetate extract of V. leucoxylon Linn. evaluated for anti-inflammatory activity in carrageenan, mediator-induced rat paw edema, and cotton pellet-induced granuloma model. The antipyretic activity was evaluated by yeast-induced pyrexia model. Results: Single administration of the ethyl acetate extract of V. leucoxylon Linn. at dose of 500 mg/kg p.o. showed significant (P < 0.001) inhibition of rat paw edema. The ethyl acetate extract showed significant antipyretic activity in brewer yeast-induced pyrexia in rats throughout the observation period of 4 h. Conclusion: This study shows that ethyl acetate extract of V. leucoxylon Linn. has significant anti-inflammatory and antipyretic activity.






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