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 REVIEW ARTICLE
Year : 2010  |  Volume : 42  |  Issue : 6  |  Page : 338-344

Novel technologies: A weapon against tuberculosis


1 Department of Pharmacy, School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamil Nadu, India
2 Department of Pharmacy, S.V. University, Thirupati, Andhra Pradesh, India

Correspondence Address:
B N Vedha Hari
Department of Pharmacy, School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.71887

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Tuberculosis (TB) is a leading chronic bacterial infection. Despite potentially curative pharmacotherapies being available for over 50 years, the length of the treatment and the pill burden can hamper patient lifestyle. Low compliance and adherence to administration schedules remain the main reasons for therapeutic failure and contribute to the development of multidrug-resistant strains. The design of novel antibiotics attempts to overcome drug resistance, to shorten the treatment course, and to reduce drug interactions. In this framework, nanotechnology appears as one of the promising approaches for the development of more effective medicines. The present review thoroughly overviews the development of novel microparticulate, encapsulation, and various other carrier-based drug delivery systems for incorporating the principal anti-TB agents. Drug delivery systems have been designed that either target the site of TB or reduce the dosing frequency with the aim of improving patient healthcare.






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