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 RESEARCH ARTICLE
Year : 2010  |  Volume : 42  |  Issue : 5  |  Page : 293-296

Kaurenic acid: An in vivo experimental study of its anti-inflammatory and antipyretic effects


Research Unit in Experimental Pharmacology, School of Medicine, Universidad Centroccidental Lisandro Alvarado, Barquisimeto, Venezuela

Correspondence Address:
Miriam C Sosa-Sequera
Research Unit in Experimental Pharmacology, School of Medicine, Universidad Centroccidental Lisandro Alvarado, Barquisimeto
Venezuela
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Source of Support: Research Council (CDCHT) of the Universidad Centroccidental Lisandro Alvarado (Grant # 016-ME-2001)., Conflict of Interest: None


DOI: 10.4103/0253-7613.70205

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Objective : This study was designed to investigate the anti-inflammatory and antipyretic effects of kaurenic acid (KA), a tetracyclic diterpenoid carboxylic acid, using in vivo experimental animal models. Material and Methods : The anti-inflammatory activity of KA was evaluated in rats, using egg albumin-induced paw edema (acute test) and Freund's complete adjuvant-induced paw edema (subacute test), whereas the antipyretic effect was studied in rabbits by peptone-induced pyresis. Acute and subacute toxicity of KA were analyzed in NMRI mice. Results : KA showed anti-inflammatory and antipyretic properties, and the effect caused was significantly dose-related (P < 0.001) in both cases. The mean lethal doses of KA were 439.2 and 344.6 mg/kg for acute and subacute toxicity, respectively. Conclusion : On the basis of these findings, it may be inferred that KA has an anti-inflammatory and antipyretic potential.






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