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 RESEARCH ARTICLE
Year : 2010  |  Volume : 42  |  Issue : 3  |  Page : 185-188

Determination of the antiulcer properties of sodium cromoglycate in pylorus-ligated albino rats


1 Department of Pharmacology, KLE Society College of Pharmacy, Hubli, India
2 S.N. Medical College, Agra, India

Correspondence Address:
Vivek Srivastava
Department of Pharmacology, KLE Society College of Pharmacy, Hubli
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.66844

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Objectives : To study the ulcer protective property of sodium cromoglycate in pylorus-ligated rats and the biochemical role in ulcer protection by various biochemical tests. Materials and Methods : The ulcer protective effect of sodium cromoglycate was studied using a Pyloric Ligation Model using Wistar albino rats. The antiulcer effect of sodium cromoglycate 40 mg/kg b.w., i.p., was compared with the reference drug ranitidine 27 mg/kg b.w., i.p. The ulcer index was calculated and other biochemical parameters like free acidity, total acidity, pH, mucin, pepsin and volume of gastric juice were determined. Results : Pylorus ligation showed a significant (P < 0.01) reduction in gastric volume, free acidity, total acidity and ulcer index as compared to the control. Conclusion : Sodium cromoglycate has activity equipotent to ranitidine.






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