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 RESEARCH ARTICLE
Year : 2010  |  Volume : 42  |  Issue : 2  |  Page : 90-94

Reproductive toxicity of sodium valproate in male rats


1 Department of Pharmacology, Kasturba Medical College, Manipal, India
2 Department of Anatomy, Maleka Manipal Medical College, Manipal, India
3 Department of Pharmacology, Maleka Manipal Medical College, Manipal, India

Correspondence Address:
Laxminarayana Bairy
Department of Pharmacology, Kasturba Medical College, Manipal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.64503

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Objectives: To assess the effects of sodium valproate on rat sperm morphology, sperm count, motility, and histopathological changes in testis. Materials and Methods: Male Wistar rats (12 week old) were treated with sodium valpraote and sacrificed at the end of 2 nd , 4 th , 5 th , 7 th , 10 th and 15 th week after the last exposure to sodium valproate. Epididymal sperm count, sperm motility, sperm morphology, and histopathology of testes were analyzed. Results: Sperm count and sperm motility were decreased significantly by sodium valproate. The percentage of abnormal sperms increased in a dose-dependent manner. A histopathological study revealed that sodium valproate had caused sloughing of epithelial cells in testes. Conclusion: Sodium valproate causes reversible change in sperm motility, sperm count, morphology, and cytoarchitecture of testes.






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