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 RESEARCH ARTICLE
Year : 2009  |  Volume : 41  |  Issue : 6  |  Page : 268-272

Effect of magnesium oxide on the activity of standard anti-epileptic drugs against experimental seizures in rats


1 Department of Pharmacology, Bharati Vidyapeeth Medical College, Pune, India
2 Department of Pharmacology, B.J. Medical College, Pune, India

Correspondence Address:
Priti Pravin Dhande
Department of Pharmacology, Bharati Vidyapeeth Medical College, Pune
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.59926

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Objectives : To study the effect of oral magnesium oxide supplementation alone and on the activity of standard anti-epileptic drugs in the animal models of maximal electroshock seizures (MES) and chemically (pentylenetetrazole [PTZ])-induced seizures. Methods : Healthy male albino rats were given magnesium oxide (MgO) supplementation orally in various doses (500, 750 and 1000 mg/kg /day) for 4 weeks (day 1 to day 28). On day 0 and day 29, response to MES (180 mA for 0.2 s) was tested 1 h after pre-administration of phenytoin or carbamazepine orally. Similarly, in the other groups, the response to PTZ 40 mg/kg i.p. was tested 1 h after pre-administration of oral sodium valproate. Results : Oral administration of MgO in a low dose (500 mg/kg) for 4 weeks in healthy rats appears to exert protective effect against MES. High oral doses of MgO (750 and 1000 mg/kg) appear to enhance the activity of phenytoin and carbamazepine in the MES model. MgO supplementation was seen to decrease the latency of PTZ-induced seizures. Conclusion : The dose of oral MgO appears to have an inverse relation with the protective effect in MES-induced seizure model. High doses of MgO supplementation given orally appear to enhance the activity of standard anti-epileptic drugs in the MES-induced seizure model.






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