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 RESEARCH ARTICLE
Year : 2009  |  Volume : 41  |  Issue : 3  |  Page : 106-109

Disposition kinetics of sparfloxacin in healthy, hepatopathic, and nephropathic conditions in chicken after single intravenous administration


Department of Pharmacology and Toxicology, West-Bengal University of Animal and Fishery Sciences, 68 KB Sarani, Kolkata-37, India

Correspondence Address:
T K Mandal
Department of Pharmacology and Toxicology, West-Bengal University of Animal and Fishery Sciences, 68 KB Sarani, Kolkata-37
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.55204

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Objective: To study the variation of disposition kinetic values of sparfloxacin in healthy, hepatopathic, and nephropathic chickens after a single intravenous administration. Materials and Methods: Hepatotoxicity was induced by the administration of paracetamol (500 mg / kg / day, p.o. for seven days) and nephrotoxicity by uranyl nitrate (2.0 mg / kg / day dissolved in distilled water, i.v. for four days) in chickens. Disposition kinetic studies of sparfloxacin were investigated in healthy as well as hepatopathic and nephropathic birds after a single intravenous administration at 40 mg / kg body weight. Results: Maximum plasma concentration detected at 0.16 hour was 31.25 ± 2.95, 61.95 ±1.85, and 99.86 ± 2.21 mg / ml in healthy, hepatopathic, and nephropathic group, respectively. The drug could not be detected in the plasma of healthy birds beyond 12-hour period, while the same was detectable for 72 hour in the plasma of hepatopathic and nephropathic birds. The concentration of sparfloxacin was significantly (P < 0.01) higher in all the samples of hepathopathic and nephropathic birds compared to healthy birds. All the kinetic values were increased (P < 0.01) in the hepatopathic and nephropathic birds, except Vd area and Cl B values in hepatopathic Birds; while β and Cl B values nephropathic birds were decreased significantly than that of healthy birds. Conclusions: The dose of sparfloxacin may be reduced in hepatopathic as well as nephropathic birds.






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