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 RESEARCH ARTICLE
Year : 2008  |  Volume : 40  |  Issue : 6  |  Page : 261-265

The effect of Allium sativum on ischemic preconditioning and ischemia reperfusion induced cardiac injury


1 Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, India
2 Department of Pharmacology, Govt. Medical College, Amritsar, India

Correspondence Address:
Jatinder Singh
Department of Pharmacology, Govt. Medical College, Amritsar
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.45152

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In the present study, the effect of garlic (Allium sativum) extract on ischemic preconditioning and ischemia-reperfusion induced cardiac injury has been studied. Hearts from adult albino rats of Wistar strain were isolated and immediately mounted on Langendorff's apparatus for retrograde perfusion. After 15 minutes of stabilization, the hearts were subjected to four episodes of 5 min ischemia, interspersed with 5 min reperfusion (to complete the protocol of ischemic preconditioning), 30 min global ischemia, followed by 120 min of reperfusion. In the control and treated groups, respective interventions were given instead of ischemic preconditioning. The magnitude of cardiac injury was quantified by measuring Lactate Dehydrogenase and creatine kinase concentration in the coronary effluent and myocardial infarct size by macroscopic volume method. Our study demonstrates that garlic extract exaggerates the cardio protection offered by ischemic preconditioning and per se treatment with garlic extract also protects the myocardium against ischemia reperfusion induced cardiac injury.






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