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 SHORT COMMUNICATION
Year : 2008  |  Volume : 40  |  Issue : 3  |  Page : 126-128

Evalution of anti-ulcer activity of Polyalthia longifolia (Sonn.) Thwaites in experimental animals


1 Rofel Shri GM Bilakhia College of Pharmacy, Vapi (West)-396 191, Gujarat State, India
2 R and D Leader, Schering Plough Link, Singapore Branch, Tuas West drive, Singapore 638 403, Singapore
3 Asthagiri Herbal Research foundation, Tambaram Sanatorium, Chennai-600 053, Tamil Nadu, India

Correspondence Address:
P Malairajan
Rofel Shri GM Bilakhia College of Pharmacy, Vapi (West)-396 191, Gujarat State
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.42306

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Objective: To evaluate the anti-ulcer activity of ethanol extract of leaves of Polyalthia longifolia (Sonn.) Thwaites. Materials and Methods: The ethanol extract of Polyalthia longifolia was investigated for its anti-ulcer activity against aspirin plus pylorous ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats at 300 mg/kg body weight.p.o. Results: A significant (P <0.01, P <0.001) anti ulcer activity was observed in all the models. Pylorous ligation showed significant (P<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. It also showed 89.71% ulcer inhibition in HCl- Ethanol induced ulcer and 95.3% ulcer protection index in stress induced ulcer. Conclusion: This present study indicates that P. longifolia leaves extract have potential anti ulcer activity in the three models tested.






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