IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1064 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed12903    
    Printed179    
    Emailed9    
    PDF Downloaded1842    
    Comments [Add]    
    Cited by others 15    

Recommend this journal

 

 REVIEW ARTICLE
Year : 2008  |  Volume : 40  |  Issue : 2  |  Page : 49-58

A review on plant-derived natural products and their analogs with anti-tumor activity


1 A.R College of Pharmacy affiliated to Sardar Patel University, Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 120, India
2 Maliba Pharmacy College affiliated to Veer Narmad South Gujarat University, Gopal Vidyanagar, Tarsadi, Ta-Bardoli, Dist-Surat, Gujarat - 394 350, India

Correspondence Address:
K K Dholwani
A.R College of Pharmacy affiliated to Sardar Patel University, Vallabh Vidyanagar, Dist. Anand, Gujarat - 388 120
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.41038

Rights and Permissions

Traditional medicines, including Chinese herbal formulations, can serve as the source of potential new drugs, and initial research focuses on the isolation of bioactive lead compound(s). The development of novel plant-derived natural products and their analogs for anticancer activity details efforts to synthesize new derivatives based on bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design - based modification. Also, the anticancer activity of certain natural products and their analogs can be enhanced by synthesizing new derivatives based on active pharmacophore models; drug resistance and solubility and metabolic limitations can be overcome by appropriate molecular modifications; and new biological properties or mechanisms of action can be added by combining other functional groups or molecules. Preclinical screening for in vitro human cell line panels and selected in vivo xenograft testing then identifies the most promising drug development targets.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow