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 RESEARCH PAPER
Year : 2007  |  Volume : 39  |  Issue : 3  |  Page : 151-154

Evaluation of the antioxidant potential of NR-ANX-C (a polyherbal formulation) and its individual constituents in reversing haloperidol-induced catalepsy in mice


1 Department of Biochemistry, Kasturba Medical College, Mangalore, Karnataka, India
2 Department of Pharmacology, Kasturba Medical College, Mangalore, Karnataka, India

Correspondence Address:
M Nandini
Department of Biochemistry, Kasturba Medical College, Mangalore, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.33435

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Objective : To evaluate the possible role of the antioxidant activity of the polyherbal formulation, NR-ANX-C and its individual components in reversing haloperidol-induced catalepsy in Swiss albino mice. Materials and Methods : Catalepsy was induced with haloperidol (1 mg/kg i.p) in 13 groups of male albino mice (n = 6 / group). Three groups received NR-ANX-C (10, 25, 50 mg/kg), three groups received Withania somnifera (1.7, 4.25, 8.5 mg/kg), another three groups Ocimum sanctum (1.7, 4.25, 8.5 mg/kg), three other groups Camellia sinensis (3.4, 8.5, 17 mg/kg) and one group received the vehicle (1% Gum acacia) orally, 30 minutes prior to haloperidol administration, for a duration of seven days. Animals were sacrificed on the seventh day and superoxide dismutase (SOD) activity was estimated in the brain. Results : A significant (P < 0.01) reduction in the cataleptic scores was observed in all the drug-treated groups as compared to the control, with maximum reduction in the NR-ANX-C 25 mg/kg group. Similarly, a reduction in SOD activity was observed in the NR-ANX-C-, O. sanctum- and the W. somnifera-treated groups. An increase in SOD activity was observed in the C. sinensis-treated groups. Conclusion : With the exception of C. sinensis, the antioxidant potential of NR-ANX-C and its individual constituents has contributed to the reduction in the oxidative stress and the catalepsy induced by haloperidol administration.






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