IPSIndian Journal of Pharmacology
Home  IPS  Feedback Subscribe Top cited articles Login 
Users Online : 1685 
Small font sizeDefault font sizeIncrease font size
Navigate Here
 »   Next article
 »   Previous article
 »   Table of Contents

Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed12018    
    Printed237    
    Emailed26    
    PDF Downloaded1442    
    Comments [Add]    
    Cited by others 27    

Recommend this journal

 

 RESEARCH PAPER
Year : 2007  |  Volume : 39  |  Issue : 1  |  Page : 43-47

Hepatoprotective activity of alcoholic and aqueous extracts of leaves of Tylophora indica (Linn.) in rats


1 Department of Pharmacology, V. L. College of Pharmacy, Raichur, India
2 Department of Pharmaceutical Chemistry, V. L. College of Pharmacy, Raichur, India

Correspondence Address:
Venkat N Rao
Department of Pharmacology, V. L. College of Pharmacy, Raichur
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0253-7613.30763

Rights and Permissions

Objective: To investigate the hepatoprotective activity of alcoholic (ALLT) and aqueous (AQLT) extracts of leaves of Tylophora indica (asclepiadaceae) against ethanol-induced hepatotoxicity. Materials and Methods: Leaf powder of Tylophora indica was successively extracted with alcohol and water. Preliminary phytochemical tests were done and the LD50 values for both extracts determined. The hepatoprotective activity of the ALLT and AQLT were assessed in ethanol-induced hepatotoxic rats. Results: The ALLT showed presence of alkaloids, carbohydrates, steroids, saponins and triterpenes, while alkaloids, carbohydrates and saponins were present with AQLT. The ALLT did not produce any mortality even at 5000 mg/kg while LD50 of AQLT was found to be 3162 mg/kg. Ethanol produced significant changes in physical (increased liver weight and volume), biochemical (increase in serum alanine transaminase, aspartate transaminase, alkaline phosphatase, direct bilirubin, total bilirubin, cholesterol, triglycerides and decrease in total protein and albumin level), histological (damage to hepatocytes) and functional (thiopentone-induced sleeping time) liver parameters. Pretreatment with ALLT or AQLT extract significantly prevented the physical, biochemical, histological and functional changes induced by ethanol in the liver. Conclusion: The present study indicates that ALLT and AQLT extracts possessed hepatoprotective activity. The alcoholic extract was found to exhibit greater hepatoprotective activity than the aqueous extract.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Site Map | Home | Contact Us | Feedback | Copyright and Disclaimer
Online since 20th July '04
Published by Wolters Kluwer - Medknow